Update on nitrate tolerance.

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An update on nitrate tolerance: can it be avoided?

Organic nitrates have been recognized by physicians as potent vasodilators and effective therapy for angina pectoris for over 100 years."2 Despite the advent of beta-blockers and calcium channel antagonists in the 1960s the organic nitrates remain important antianginal agents and are well-established as the drugs of choice in acute angina. Recently interest in nitrate therapy has increased as a...

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An update on nitrate tolerance: can it be avoided?

Organic nitrates have been recognized by physicians as potent vasodilators and effective therapy for angina pectoris for over 100 years."2 Despite the advent of beta-blockers and calcium channel antagonists in the 1960s the organic nitrates remain important antianginal agents and are well-established as the drugs of choice in acute angina. Recently interest in nitrate therapy has increased as a...

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Effects of Atorvastatin on Nitrate Tolerance in Diabetic Rats

Statins have been reported to show preventive effect on nitrate tolerance in normal rats, but there are no reports on their effect in diabetic animals. In this study, diabetes was induced in male wistar rats by a single intraperitoneal injection of streptozotocin (45 mg/kg). Five groups of diabetic and five groups of normal rats were treated; groups 1 (of normal and diabetic rats) received ator...

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Effects of Atorvastatin on Nitrate Tolerance in Diabetic Rats

Statins have been reported to show preventive effect on nitrate tolerance in normal rats, but there are no reports on their effect in diabetic animals. In this study, diabetes was induced in male wistar rats by a single intraperitoneal injection of streptozotocin (45 mg/kg). Five groups of diabetic and five groups of normal rats were treated; groups 1 (of normal and diabetic rats) received ator...

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Antioxidants and nitrate tolerance.

authors and five references. They should not have tables or figures and should relate solely to an article published in Circulation within the preceding 12 weeks. Only some letters will be published. Authors of those selected for publication will receive prepublication proofs, and authors of the article cited in the letter will be invited to reply. Replies must be signed by all authors listed i...

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ژورنال

عنوان ژورنال: British Journal of Clinical Pharmacology

سال: 1992

ISSN: 0306-5251

DOI: 10.1111/j.1365-2125.1992.tb04142.x